Angelica on the cardiovascular system

Effects on the cardiovascular system

1. Effect on the heart

Dahe He et al. reported that isolated heart 灌 perfusion experiments showed that volatile oil contained in Angelica decoction or roots and leaves can significantly inhibit the frequency of myocardial contraction. Zhang Shufang, etc. to iv administration of the abdominal wall, indicating that the majority of body iliac heart complete atrioventricular block, atrial contractility was significantly reduced later gradually recover, the frequency slowed, but the ventricular contractility but increased. Wei Lianxi reported that Angelica sinensis extract can extend the atrial refractory period in rabbits and have a therapeutic effect on acetylcholine or current-induced anesthetic cats and dogs. The above-mentioned quinidine-like active ingredients are mainly found in ether extracts. Things. According to a report from the Institute of Traditional Chinese Medicine in Jiangsu Province, angelica extract and ether extracts can reduce myocardial excitability and significantly prolong the refractory period. In 1981, Peng Renxuan and others used isotope tracer method to show that Angelica sinensis flow extract (30g/kg) can increase the ability of myocardial uptake of 86Rb in mice, and it can alleviate the myocardial ischemia induced by pituitrin. Zhou Yuanpeng et al.'s research shows that Angelica Injection IV can reduce the degree of experimental myocardial ischemia and slow down the heart rate of some anesthetized dogs by temporarily blocking the coronary blood flow for a short time. However, it increases the severity of myocardial ischemia in conscious dogs. accelerate. According to another report, Angelica decoction, water extract and its active ingredient, ferulic acid sodium, can increase the ability of mice to take up 86Rb, and increase the myocardial nutrient blood flow by 36.3%, 40.6% and 46% respectively, indicating that angelica energy Increase the opening of myocardial capillary vessels. Iv. Angelica injection can reduce the myocardial infarct size in anesthetized dogs with coronary occlusion (P<0.001). Experiments by Xu Jingya et al. showed that rabbits given iv 25% Angelica injection (2 ml/kg/dose) had a similar effect to propranolol (0.75 mg/kg/dose) in reducing the range of experimental myocardial infarction, compared with the control group. Angelica group and propranolol group reduced myocardial infarction range by 37.5% and 47.9% respectively, there was no significant difference between the two groups.

Angelica (13 photographs)(P<0.05). And heartlessness is obviously slowed down as innocently. Iv200% Angelica injection 1g/kg had no significant effect on left ventricular systolic and diastolic function of anesthetized dogs.

2. Antiarrhythmic effects

Angelica sinensis extract and ethanol extract have obvious antagonistic effects on a variety of animal-induced arrhythmias induced by epinephrine, cardiac glycosides, and cesium chloride, etc. Ex vivo guinea pig ventricular myocardium experiments showed that angelica alcohol extract and ferulic acid Sodium injection can counteract the arrhythmia caused by scapegoatosis and ouabain poisoning, and make it turn into a normal rhythm; Angelica can also slow down the rat heart rhythm-promoting effect caused by goldenrod. Iv alcohol extract also had a significant preventive effect on arrhythmia induced by aconitine in anesthetized rats (P<0.001). It was also reported that im Angelica extract can not prevent and treat various arrhythmias caused by aconitine, and can not fight arrhythmia caused by chloroform, nor can it increase the left ventricular tremor threshold in rabbits. In 1985, Zhong Zhongmin et al's electrophysiological studies confirmed that the extract of Angelica sinensis had a very similar quinidine-like effect, but also significantly prolonged the plateau period. It was inferred that the antiarrhythmic effect of Angelica sinensis alcohol extract may be to slow the conduction and prolong the effective period. During the application period, the effects of multiple actions such as reentry, prolongation of the plateau period, inhibition of ectopic rhythm points, and improvement of the tremor threshold were eliminated. In 1989, Zhu Yuzhen et al. performed an anti-arrhythmic study on the total acidity of Angelica sinensis in water-soluble constituents of Angelica sinensis. The results showed that Angelica sinensis acid-induced arrhythmias induced by chloroform, adrenaline, aconitine and barium chloride in animals. There are obvious protective effects, and its antiarrhythmic effect may be related to reducing cardiac excitability and prolonging myocardial refractory period.

3. Hypolipidemic and anti-atherogenic effects

According to the research data of the Jiangsu New Medical College, Angelica powder 1.5g/kg has reduced blood lipids in experimental hyperlipidemia in rats and rabbits, and its hypolipidemic effect is not due to the inhibition of cholesterol absorption. The food containing 5% Angelica powder and the equivalent amount of Angelica oil and other extracts had a protective effect on aortic lesions of experimental atherosclerotic rats. Reports from the General Hospital of Shenyang Military Region indicated that Compound Angelica Injection (Danggui, Chuanxiong, and Safflower) could increase coronary artery flow in anesthetized dogs and isolated rabbits, prevent T wave increase caused by pituitrin, and slow down the heart rate caused by it. , Lowering experimental hyperlipidemia rabbit triglycerides. It can also significantly increase the plasmin activity in patients with coronary heart disease and cerebral arteriosclerosis.

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