Zhejiang Medical Second Hospital: Extracting stem cells from urine to help treat cataract

Zhejiang Medical Second Hospital: Extracting stem cells from urine to help treat cataract

September 28, 2016 Source: Zhejiang Second Hospital

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This time, it is a big gathering in the field of ophthalmology. In the past few days, Wang Ningli, Xie Lixin, Zhao Kanxing, Li Xiaoxin, Zhao Jialiang and other ophthalmology doctors all over the country were invited by Professor Yao Ke, the chairman of the Ophthalmology Branch of the Chinese Medical Association and the director of the Zhejiang Eye Center. Gathered at the West Lake. There were also experts from the United States, Japan, and South Korea. Some of them just attended the Suzhou National Eye Clinic last week and rushed to Hangzhou.
 
So many experts are coming to congratulate the 20th anniversary of the establishment of the Zhejiang Second Eye Center. At the same time, they also bring the most cutting-edge information at home and abroad. Femtosecond lasers, precision medicine, multi-focal crystals... every message is delightful.
 
1. Extracting stem cells from urine to deal with cataracts will be a revolution.
 
In the past two decades, Professor Yao Ke has promoted five technological innovations in domestic cataract surgery. At the meeting, he also revealed the team's latest research: it has successfully extracted stem cells in the urine, which will help the diagnosis and treatment of cataract in the future.
 
For stem cells (an under-differentiated, immature cell with the potential to regenerate various tissues and organs and the human body, the medical community calls it "universal cells"), experts all over the world are doing their best to do research. . Ophthalmology is no exception, especially in the field of cataracts.
 
Professor Yao Ke said that the lens in the eye becomes cloudy, which is the leading cause of vision loss and blindness in cataract patients. The current treatment is to remove the opaque lens and implant the intraocular lens.
 
How to make treatment more perfect? A revolution is taking place: using stem cell technology to "regenerate" the original lens.
 
At present, ophthalmologists are continually trying to extract the stem cells of the human body and induce them in vitro by various methods to grow them into new lenses. The larger the diameter, the more transparent the better.
 
Previously, American experts had the most powerful technology and had developed a lens body with a diameter of 0.5 mm.
 
However, this record was broken by China. Professor Yao Ke's team has successfully extracted stem cells in the urine, using the new in vitro "powdered egg" technology, induced a 3mm lens body in 25 days, and the body is very transparent. This not only lays an important foundation for the personalized transplantation of "regeneration" lens in the future, but also provides a new idea of ​​"testing" for new drug development, drug screening and therapeutic evaluation of cataract.
 
Professor Yao Ke explained that using the patient's stem cells, the lens of the original lesion can also be induced, and the drug test is first performed on this to see the effect. The subsequent treatment will be more precise and more targeted.
 
The relevant papers of this research have been submitted to the top international academic journals. Although the paper has not been officially published, American experts can't wait to find a door to cooperate.
 
2. Strong dialogue between the top ten eye centers in China and the United States
 
At the earliest, Professor Yao Ke revealed the research progress of stem cells at the annual National Ophthalmology Annual Meeting in Suzhou.
 
At the Ophthalmology Annual Meeting, more than 10,000 ophthalmologists (the equivalent of one-third of the country's ophthalmologists) came to the forefront. The top ten ophthalmology centers in China and the United States had an unprecedented dialogue.
 
Professor Yao Ke, director of the Zhejiang Second Eye Center, one of the national key (cultivation) disciplines and one of the national TOP10 ophthalmology centers, and Professor Yao Ke, director of the Institute of Ophthalmology, Zhejiang University, introduced the development of ophthalmology in China and the Center of Ophthalmology from Zhejiang Research.
 
In addition to stem cells, Professor Yao Ke has done a lot of work on the basic research of congenital cataract. Among the internationally identified congenital cataract-related mutations, 30 mutations were discovered by Professor Yao Ke's team and their functions were further studied.
 
Professor Yao Ke is also the vice president of the Asia-Pacific Cataract and Refractive Surgery Society and a guest of all major international ophthalmology conferences. He mentioned that after several generations of efforts, most of the technology of our ophthalmology has been synchronized with the international, and has developed a development track of introduction, absorption, digestion, innovation, and then lead.
 
We speak with data
 
At present, the number of scientific research articles published by international ophthalmology circles in China is second only to the United States, especially in influential magazines and periodicals such as Nature, Science and Lancet. Chinese original article.
 
"With the full femtosecond laser, it has accounted for 60% of our center's annual myopia laser surgery. At present, China is the country with the largest number of full femtosecond operations, the largest number of machines, the most papers, and the most advanced technology. Professor Yao Ke said.
 
On the topic of ophthalmology development, the academic conference of the 20th anniversary of the establishment of the Zhejiang Second Eye Center has aroused the resonance of the three generations of ophthalmologists.  
 
At the beginning of the establishment of the Zhejiang Eye Center, there were only 11 doctors and 25 beds, which was the smallest department in the hospital. After 20 years of development, the cataract, fundus disease, refractive surgery, eye plastic surgery and eyelid disease, glaucoma, eyesight and other specialties have more flowers, and the number of staff has increased to more than 380.
 
The number of outpatient clinics in the largest ophthalmology center in the United States is 300,000 a year, while the annual outpatient volume of the Zhejiang Eye Center is as high as 600,000, and the number of surgeries in various types has exceeded 55,000. It has become a large-scale modern ophthalmology center integrating medical treatment, teaching and research. It is the key laboratory for the prevention and treatment of important blind eye diseases in Zhejiang Province and the supporting unit of the Institute of Ophthalmology of Zhejiang University.
 
They let the world know: the development of ophthalmology, the voice of Hangzhou is very important, and the voice of China is very important.
 
On the weekend, he almost always goes back and forth on the plane.
 
If you miss a clinic, you should also inform the patient to make up.
 
The development of an ophthalmology center is inseparable from the persistence and efforts of the doctors and the team.
 
When interviewing Professor Yao Ke, he was preparing for the next day's surgery. Several students secretly said, "The teacher is too busy. He has to participate in many work of the CPPCC, the Peasants' Democratic Party, the school, and the medical association. He is almost on the plane every weekend."
 
Even so, Professor Yao Ke twice in the clinic and two operations a week, the thunder does not move.
 
Like before, he went to the Asia Pacific Cataract and Refractive Surgery Society (APACRS) to award the Gold Award and the Chinese Physician Award. After returning to the hospital, he asked the nurse to inform the patient and fill the clinic and surgery.
 
In 1997, Professor Yao Ke founded the “Zhejiang Blind Recovery Fund” and the country’s first “Automotive Eye Hospital”. He has been busy with work. He has been insisting on personally performing surgery for grassroots poor patients. So far, the team has implemented more than 7,200 free rehabilitation operations for poor patients in Zhejiang, Tibet, Xinjiang, Inner Mongolia, Guizhou, and Gansu. On Monday, the Automotive Eye Hospital set off again to Kaihua. The machine was installed non-stop, screening patients, and performing surgery. Although it was very tired, the doctors at the Zhejiang Second Eye Center said, "We are tirelessly reviving perpetual motion."
 
postscript
 
The influence of a doctor is beyond imagination, to colleagues, students, and to patients.
 
I remember a detail, the patient who had an anxiety before surgery, Professor Yao Ke will habitually hold his hand, whispered, "I am Dr. Yao, I am going to give you a knife." After talking, the patient suddenly calmed down and even the blood pressure followed normal.
 
Someone asked, what do you think is the most perfect happiness?
 
Professor Yao Ke’s answer is that the patient has recovered and told me “thank you”.
 
Just like he wrote on the commemorative album of the 20th anniversary of the establishment of the Zhejiang Second Eye Center -
 
Your light, my wish.

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