Release date: 2013-07-05
According to foreign media reports, scientists plant micro-liver in the laboratory, which is a huge progress for transplant patients. This technology will one day be used to repair organs damaged by disease or trauma, and people will no longer suffer from waiting for transplants.
New kidneys, lungs and pancreas can also be cultivated using the same techniques. The study is still in its early stages, but British scientists say it is a "great advancement" and offers an alternative to organ transplantation.
More than 7,000 Britons are on the transplant list, including 154 children. Except for 500 waiting for the liver and 200 waiting for the lungs, most of them are waiting for the kidney.
Japanese researchers used microplates in three different liver cells of human embryos in culture dishes. It is then grafted onto the rat brain, which provides blood for it, and the tissue block can grow on the rat brain for at least two months.
Artificial tissue has many of the characteristics of a normal human liver, including the ability to metabolize drugs. In the experiment, artificial tissue can also prolong the lifespan of lethal liver disease mice. The results of the study have been published in the journal Nature. The reason for choosing the rat brain is because it is convenient for grafting and observation.
For human patients, tissue blocks will be used for actual liver repair. In the next decade, scientists hope to conduct human trials. Takamori Takebe, a researcher at Yokohama City University, said the first test was most likely an infant or child with severe liver disease. But in time, adults will also benefit. He believes that the liver repair of the cultivated tissue is better than the transplant surgery, and has broad application prospects in the future transplant needs.
Scientists believe that this technology will replace real human trials in the development of new drugs, avoiding the tragedy caused by clinical drug trials. At the same time, the development of this technology will provide more choices for organ transplantation and reduce the death of donors due to shortage of donor organs.
Source: Kexun
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