Release date: 2014-06-18
Kidney disease is a major and unresolved health problem worldwide, and the irreversibility of kidney disease development has plagued patients, doctors and researchers. Researchers at Wenzhou Medical University successfully induced renal regeneration in a partially nephrectomized rat model by using allogeneic kidney decellularized bioscaffolds. Related research results "Decellularization-induced kidney regeneration" has recently been published in the world's leading journal Biomaterials in the field of biomaterials.
According to statistics, there are 120 million people with kidney disease in China. It has been widely believed in international research fields that vertebrates other than zebrafish cannot achieve kidney regeneration in the body. The partial nephrectomy model in rats can detect the regenerative regeneration of the tubules only at the resected stump, and the glomerular regeneration cannot be detected, and the function is permanent loss. Researchers in the field of kidney regeneration have all realized the regeneration of glomeruli and the restoration of function as the ultimate goal of research.
On the basis of the successful preparation of the kidney decellularized biological scaffold, the scientific research team of Wenzhou Medical University completely removed the rat kidney cells, only retained the three-dimensional extracellular matrix structure of the kidney, and transplanted the cell-free bioscaffold to the partially nephrectomized rats. On the kidney, the rat's residual kidneys are regenerated. After the operation, gross and B-ultrasound showed an increase in the morphology of the experimental kidney. The glomerular filtration rate of the experimental kidney was gradually increased after radionuclide detection, and a large number of precursor cells appeared in the experimental kidney by immunological methods. And is regularly distributed.
Associate Professor Mei Jin, Executive Director of the Institute of Biological Stent Transplantation and Immunology, Wenzhou Medical University, said that the research results were funded by the Natural Science Foundation of Zhejiang Province, marking the significant breakthrough in the research field of the decellularized bio-stent research team at Wenzhou Medical University. In the future, it will open an important path for clinical treatment and scientific research of patients with kidney disease.
Source: Kexun
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