Cancer, cardiovascular disease, chronic enteritis, flu... These diseases are the enemies of human health. How to efficiently develop relevant therapeutic drugs is a problem that scientists have been exploring. On March 24th, Chongqing Daily reporter learned from Chongqing University that the DNA encoding molecular library technology used by the school's School of Pharmacy and the Swiss Federal Institute of Technology in Zurich will hopefully quickly find active compounds that target these diseases, thereby enhancing the development of related drugs. The speed and quality. A few days ago, this research was published in the journal Nature and Chemistry.
"If the molecules in the molecular library are likened to numerous keys, then the target for curing a disease is the lock that needs to be opened." Li Yizhou, a researcher at the Chongqing University School of Pharmacy, said that the development of new drugs is Finding the key to open a certain lock in numerous keys, and the traditional way of selecting the key is very slow, that is, the high-throughput drug screening technology currently adopted by multinational pharmaceutical companies. "It uses a large-volume paired screening method that is less efficient. It takes about 20 years to synthesize and screen 500 to 6 million molecules. It has a long research and development cycle and large capital investment. Even if new drugs are developed, the price will be very high."
The DNA-encoding molecular library technology used by the School of Pharmacy of Chongqing University and the Swiss Federal Institute of Technology in Zurich, Switzerland, took more than 3 years to synthesize 35 million different compounds, and then used coding technology for each compound. Both are affixed with unique DNA barcodes.
The 35 million different compounds were contained in a small test tube. Then, it quickly matches the disease target in another test tube to find the active compound against the disease target. After these compounds are found, they can be sequenced and the relevant drugs can be developed in a targeted manner.
"At present, many diseases use antibody drugs for treatment. Compared with chemical small-molecule drugs, antibody drugs are expensive to manufacture, and antibody drugs usually need to be injected. They are not as convenient as chemical small molecule drugs such as tablets for taking, keeping and carrying. Li Yizhou said, therefore, if the use of DNA encoding molecular library technology, not only can greatly accelerate the development of new drugs, but also help reduce patient suffering.
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