Release date: 2017-10-16
Credit: Ruijing Creative
According to the World Health Organization, the situation of human visual impairment is still quite serious. About 285 million people worldwide are classified as visually impaired, and about 39 million of them are blind. Fortunately, 80% of visual impairment can now be treated or cured unless it is completely blind, especially severe retinal degeneration.
Laboratory tests at Oxford currently demonstrate the potential to restore the visual function of the blind.
In a study published in the Proceedings of the National Academy of Sciences (PNAS), researchers at the University of Oxford, led by Samantha de Silva, showed how to restore the vision of blind patients who were previously thought to be irreversible.
The researchers wrote: "Due to the gradual loss of photoreceptor cells, hereditary retinal degeneration may lead to blindness. Our study used adeno-associated viral vectors to assess retinal transmission of human melanin and used retinal cells as a model of retinal degeneration. â€
Using gene therapy, researchers found a viral vector in the back of the eye that was initially insensitive to light. The viral vector introduces a light-sensitive protein called melanin that causes these residual retinal cells to respond to light and transmit visual signals to the brain.
The researchers conducted experiments in mice with retinitis pigmentosa, one of the most common causes of blindness in young people. Through this experiment, the researchers kept blind mice more than a year old. Rats exhibit a high degree of visual perception and are able to recognize objects in the environment.
More notably, de Silva and her colleagues also successfully tested an electronic retina. As a result, they observed that this gene therapy may be simpler and easier to implement.
Researchers have also conducted similar experiments in other age-related blind people, and the US Food and Drug Administration approved the gene therapy to try to treat hereditary retinal blindness. De Silva pointed out that the results of the experiment prove that this therapy will bring great hope to blind patients.
She said in a press release: "We have a lot of blind patients in our clinic. They have the ability to use some relatively simple genetic procedures to restore some vision. This is worth our expectation. We will start clinical trials to evaluate The patient's condition."
Source: Omelette Net
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