According to Japanese media reports, a research team composed of Keio University and the Central Laboratory for Experimental Animals (Kawasaki City) published a paper on the June 30 issue of the American Science Journal Cell-Stem Cell, which can effectively alter genetics. The "gene editing" technology has successfully produced small, apes-free monkeys.
It is reported that the team is successful in the field of primates that are closer to humans than mice, and is expected to promote research on diseases.
Data Map: Monkey
Gene editing is a technique that uses genetically engineered enzymes to destroy specific genes or encode other genes. The research team destroyed the immune-related genes in the fertilized eggs of the apes to make them ineffective.
The marmoset produced by the fertilized egg has fewer lymphocytes in its blood and is very similar to the human body's congenital immunodeficiency disorder. Although no immune function is resistant to infection by pathogens, four marmosets are said to have survived in clean rooms for more than one year.
It is understood that mice that destroy genes are often used in animal experiments, but in the case of primates, it has been difficult to disable specific genes.
The director of the institute, Sasaki Erika, said: "It is not only an immunodeficiency disease, but it is hoped to help identify difficult diseases that are difficult to understand in mouse experiments such as autism and psychosis."
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