Experimental drug reversal of hair loss

Experimental drug reversal of hair loss

August 06, 2018 Source: Chinese Journal of Science

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Through a series of mouse experiments, researchers at Johns Hopkins University in the United States successfully reversed hair loss, whitening, and skin inflammation using an experimental compound. This compound stops the production of fat called glycosphingolipids or GSL, which is a major component of skin and other cell membranes. Current research indicates that mice fed a high-fat and high-cholesterol diet are more likely to change their color from black to gray to white, and have a large amount of hair loss and inflammation of the skin that manifests as a wound. However, after feeding the compound, these symptoms of the mouse were reversed. The results of this study were published in the journal Science Report.

"The results obtained in mouse experiments do not imply that the same effect will be produced in humans, and there is currently no evidence that the compound is safe for humans." Johns Hopkins University School of Medicine Pediatrics and Medical professor Subroto Chatterjee said, "Although further research is needed, it suggests that the drugs we develop will have the potential to treat skin diseases such as psoriasis and wounds caused by diabetes or plastic surgery."

To investigate whether disrupting GSL affects skin appearance and color, and whether D-PDMP, an artificial compound that stops GSL production, can reverse the negative effects of GSL, Chatterjee and colleagues first genetically engineered a group of mice to It suffers from atherosclerosis.

The researchers then divided the mice into two groups, the first group feeding high-fat and high-cholesterol foods, and the second group feeding standard foods. All mice were fed the above-specified diet from 12 weeks to 20 weeks of age. Compared to the second group of mice, the first group of mice developed hair loss, which formed skin damage and whitened hair color. The symptoms became more severe when fed to 36 weeks of age, with 75% of mice having hair loss and multiple skin lesions.

At 20 to 36 weeks of age, the two groups of mice received different amounts of D-PDMP (capsule or liquid form) while these mice were still fed the aforementioned food. The results showed that during the period from 20 weeks to 36 weeks of age, the first group of mice received 1 mg or 10 mg of capsule D-PDMP per kilogram of body weight per day, began to re-grow, and restored the coat color, and its skin inflammation also Reduced.

The team then observed the skin of the mice under a microscope and found that the first group of mice developed neutrophil infiltration in each skin area, while D-PDMP capsule treatment significantly reduced the number of neutrophils. It means that the degree of skin inflammation and injury is alleviating.

Subsequently, the researchers used mass spectrometry to determine levels of ceramide, glucosylceramide, and lactosylceramide in mice, where ceramide is a lipid or fat that helps protect the skin's moisture, and glucosylceramide is a nerve. The first derivative of amide, and lactosylceramide is a later derivative of ceramide that activates inflammation.

Compared with the second group of mice, the total ceramide levels of the first group of mice decreased, glucose ceramide decreased, and the content of lactose ceramide increased nearly three times. When treated with 1 mg capsule D-PDMP per kilogram body weight or 10 mg liquid D-PDMP per kilogram body weight, the ceramide level of the mice increased and returned to normal levels.

"I hope this study will enable bald people to restore hair growth, blacken old people's white hair, and make wound healing faster and more effective." Chatterjee expects. (Zhang Sizhen Zhao Lu)

Related paper information: DOI: 10.1038/s41598-018-28663-9

Chinese Journal of Science (2018-08-03 8th Edition Life)

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