Release date: 2015-01-30
Recently, the international biology journal cell death & development published the latest research results from a research group of Sun Yat-Sen University. They found that miR-34c is down-regulated in nasopharyngeal carcinoma (NPC) by gene chip analysis, and it has been shown that miR-34c can inhibit the growth and metastasis of nasopharyngeal carcinoma by directly inhibiting the expression of proto-oncogene MET. This study provides a mechanism for the treatment of nasopharyngeal carcinoma.
The researchers analyzed the NPC cell line and patient tissue samples and found that miR-34c was down-regulated in both cells and tissues. By overexpressing miR-34c in cell lines, NPC cell viability, colony formation, cell migration and invasion ability were significantly inhibited, and in vivo experiments also demonstrated that miR-34c overexpression inhibited tumor growth and lung metastasis. The researchers found that miR-34c can directly act on the proto-oncogene MET, and miR-34c overexpression can significantly reduce MET mRNA and protein levels. Knockdown of MET in cells inhibits proliferation, migration and invasion of NPC cells, while restoring MET expression can alter the inhibitory effect of miR-34c on tumor cells. In addition, the researchers also discovered a chemical molecule that restores miR-34c expression.
Taken together, this study found that miR-34c can inhibit the growth and metastasis of nasopharyngeal carcinoma by affecting MET expression. The discovery of a new pathway for miR-34c/MET may be a further study of the mechanism of NPC development and the development of drugs for the treatment of NPC. Provide important reference.
Source: Bio Valley
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