Biosafety cabinet performance analysis

Biosafety cabinet performance analysis

   Some people may think that the biosafety cabinet is nothing more than an iron box with a fan and some HEPA filters; in fact, the biosafety cabinet is much more complicated. Similarly, maintaining the safety of a biosafety cabinet is much more complicated than "regular replacement of filters." The purpose of this paper is to solve the problem of the safety performance of safety cabinets, and to provide guidance for laboratory staff, management personnel and other relevant personnel involved in the safety and maintenance of safety cabinets.

filter

The filter is a key component in the biosafety cabinet, which acts to filter bacteria and dust particles to purify the gas that is blown into the safe cabinet and discharged. The filter used in the safety cabinet must have sufficient filtration efficiency, otherwise it will not protect against biological hazards. The filter material should be silicate fiberglass. At present, HEPA high-efficiency filters with a cut-off efficiency of 99.99% for 0.3μm dust particles and ULPA ultra-high efficiency filters with 99.9998% cut-off efficiency are commonly used in safety cabinets. The latter has better filtration efficiency, tighter structure and larger unit filtration area, providing ISO 3 cleanliness for the work area.

Fan system

A fan system that complies with the national standard of the safety cabinet shall have the following functions: automatic air volume compensation function, which can automatically compensate the air volume to maintain the air flow rate constant within a certain range of the filter load wind pressure drop; the motor has thermal protection function, which can be Stable operation under 1.15 times rated voltage. The centrifugal external rotor fan, which has been widely recognized by the clean industry, does not need to add lubricating oil compared with the ordinary fan. It also has the characteristics of compact structure, light weight, good balance, fast heat dissipation and 100% speed control, and has good stability. Sex and longer life.

An interlock alarm system is required for the Type B2 Class II biosafety cabinet, internal and external fans, as described in more detail below.

Airflow control and the concept of “airflow safety performance zone”

Airflow control is the core technology of biosafety cabinets. As a qualified biosafety cabinet, in addition to the required airflow rate, the airflow also needs to achieve directionality, stability and uniformity to meet the requirements of biohazard testing.

The international biosafety cabinet standard has a basic airflow safety range. For example, the US NSF49 standard stipulates that the secondary biosafety cabinet inlet flow rate is 0.5m/s; the EU EN12469 specifies a small inlet airflow value of 0.40m/s. The airflow speed of the safety cabinet must be at a suitable value, neither too high nor too low. If the airflow speed is too high, it will easily cause turbulence, which will cause the test article to lose its protection; if it is too low, it will not be able to exert sufficient protection (the pollutants in the cabinet can easily escape from the work area). The speed setting of different biosafety cabinets is different. The setting speed of Zui Jia can make the safety cabinet play a large protective role. Manufacturers should perform airflow tests on all models of safety cabinets they produce to determine the airflow safety performance zone and airflow settings and provide them to the user for reference.

Shanghai Sujing Industrial Co., Ltd. is located at No. 6, Lane 358, Wencheng Road, Songjiang New City, Shanghai. It is one of the leading manufacturers in the purification equipment industry in East China. It can provide professional air purification system engineering design, construction, testing and technical services for microelectronics, biomedicine, hospital operating room, fiber optic cable, food and beverage, precision instruments, semiconductor and new materials applications according to national GMP requirements.

The company's purification workbench series, air shower room series, fume hood series, biosafety cabinet series are widely used in medical and health, electronics, pharmaceutical, biological, food, agriculture, forestry, animal husbandry and veterinary, inspection and quarantine, aerospace, automobile manufacturing, Precision instruments, universities and research institutes enjoy a high reputation in the domestic and Southeast Asian markets.

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