Release date: 2016-11-03
Cancer seems to be becoming more and more common, and almost everyone's friends and family are affected.
However, medical technology against cancer is also changing with each passing day.
San Francisco-based startup Miroculus is also developing new technologies.
Using 3D printing, Miroculus created an easy-to-use blood test device called Miriam. It can detect more than a dozen cancers from a small blood sample.
Miriam detection device
This technology is based on small-molecule RNAs, which, like signatures, produce a specific combination of small-molecule RNAs in different states. So each cancer has its own specific small RNA combination.
For this purpose, they have established the small molecular RNA database Loom.bio, which can be used by scientists and doctors all over the world.
Miriam can quickly extract small RNA from blood samples by owning a proprietary biochemical reaction mixture .
Using a unique digital microfluidic technology, each well can be tested for different small RNAs after the blood sample is added to a 96-well plate.
By combining these results, the patient's small RNA signature is obtained, which can diagnose early cancer.
They launched prototypes in 2014, and doctors only need to prepare blood samples. Then the report from the loading to the output is automatically completed.
Prototype product
Further, using 3D printing technology to create a lower-priced product - the laboratory Miriam on the chip.
Miriam
Miriam's first test was for patients with gastric cancer.
Detection of gastric cancer using Miriam
Because gastric cancer is high in developing countries. Early diagnosis can increase the 5-year survival rate from less than 50% to 90%.
Preliminary clinical trials in 650 patients in 4 countries have achieved good results.
And from these data can continue to improve the performance of this device.
Preliminary data of gastric cancer
Gastric cancer testing products are expected to be available in 2018.
Gastric cancer testing is only the beginning, and the detection devices for lung cancer and ovarian cancer have also achieved good results.
Miroculus hopes to help doctors and patients in developing countries get an earlier diagnosis and better treatment with this low-cost and efficient 3D printing device.
Their management team is a veritable multinational force, CEO Alejandro Tocigl from Chile, Chief Scientific Officer Dr. Fay Christodoulou from Greece, Chief Technology Officer Jorge Soto from Mexico, and Chief Operating Officer Dr. Irena Barbulovic-Nad from Serbia.
Management team, from left: CEO Tocigl, CSO Christodoulou, CTO Soto
As CEO Alejandro Tocigl said,
“Our devices are faster and cheaper than existing methods and can significantly reduce spending in the health care arena.â€
“Our goal is always only one, a blood test device that can detect various diseases at the molecular level.â€
Reference materials:
[1] 3D printed Miriam device can detect dozens of cancers using a single blood sample
[2] This Device Could Detect Dozens of Cancers With a Single Blood Test
[3] Miroculus Official Website
Source: Health New Vision
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