The research on the biological effect of HINEG in the strong sputum neutron source scientific device
October 24, 2018 Source: Chinese Academy of Sciences
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, the research team of the Institute of Nuclear Energy Safety Technology of the Hefei Institute of Material Science, Chinese Academy of Sciences, based on the strong current neutron source scientific device HINEG, cooperated with the Institute of Technical Biology and Agricultural Engineering of Hefei Research Institute to carry out high-energy neutron radiation damage effect experiments. The study found a range of hypersensitivity doses of high-energy neutrons to nematodes, and the results were published in the medical journal International Journal of Molecular Medicine.
The nematode has 60%~80% homologous genes in humans. It is of great significance to study the neutron radiation protection by using nematodes to carry out neutron irradiation damage effect experiments. Due to the lack of neutron sources with monochromatic, high-energy and high-current neutrons, research on radiation damage of high-energy neutrons has been rare in the world.
This experiment is based on the strong flow neutron source scientific device HINEG, which is led by the research team of the Nuclear Energy Safety Institute. It can generate DC steady-state single-energy or mixed-spectrum neutrons with a neutron flux of 6.4×1012 n/s. At the same level as the same type of equipment in the world. The experiment found that at the individual level, high-energy neutron radiation showed a clear dose-positive correlation with the life span and offspring of the organism, and high-energy neutrons also showed hypersensitivity in a specific low-dose range (~2 Gy); At the cellular level, high-energy neutrons can trigger HO-1 (heme oxidase-1)-mediated stress protection mechanisms, which are usually activated when the body is exposed to free radicals, ultraviolet radiation, etc. A new direction for high-energy neutron radiation protection.
This study not only provides a scientific basis for high-energy neutron low-dose radiation protection, but also provides guidance for the clinical dose setting of tumor radiotherapy and the development of new anti-radiation drugs. The research team said that as an important experimental platform for advanced nuclear energy system research and development and nuclear technology cross-application research, HINEG is open to collaborative experiments for researchers at home and abroad.
High energy neutron radiation induced nematode longevity and high energy neutron radiation damage pathway
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