Many drugs have a very pungent, unpleasant taste and are difficult for patients to take. The main purpose of the boiling coating machine is to improve the appearance and easy to identify, cover up bad smell, facilitate patient swallowing, reduce gastrointestinal reactions, control drug release, change drug release curve, and also protect against moisture, light, and air to increase drugs. Stability. Compared with sugar coating, it has the characteristics of short production cycle, less material consumption and strong moisture resistance. In the coating process, depending on the solvent, it can be divided into a water-soluble coating process and an organic solvent coating process.
Boiling coating machine 3 different coating methods:
1. Fluidized coating method: The principle of fluidized coating and granulation is basically similar to the principle of fluidized granulation. The core is placed in a fluidized bed, and the airflow is introduced into the airflow. Suspended in the coating chamber, flipped up and down in a fluidized (boiling) state, and then sprayed a solution or suspension of the coating material into the fluidized bed in an atomized state, uniformly distributing a coating material on the surface of the core, and Heat the air to dry it, and repeat the coating until the specified requirements are met.
2, roll coating method, also known as pan coating method, is a classic and widely used coating method, can be used for sugar coating, film coating and enteric coating, including ordinary roll coating method and buried tube Coating method.
Coating pan: It is usually made of a material that is stable and has good thermal conductivity, such as copper or stainless steel, and is often in the shape of a dome.
3. Pressing and coating method: Generally, two tablet presses are combined to implement the press coating, which is to connect two rotary tablet presses with a single drive shaft.
In the coating, after the material is pressed into a core by a tableting machine, the core is transferred by the transfer device to the die hole of the other tableting machine, and the off-chip is taken by the getter pump during the transfer process. The fine powder is removed, and before the core reaches the second tablet press, a part of the coating material is filled in the die hole as a bottom layer, and then the core is placed thereon, and then the coating material is added to fill the die hole, and the first The second press is made into a coated tablet.
The coating method can avoid the adverse effects of moisture and high temperature on the medicine, has short production process, high degree of automation and good working conditions, but has high requirements on the precision of the tableting machine.
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