According to the website of the Ministry of Science and Technology, in order to analyze and explore the type and mechanism of autophagy induced by human parainfluenza virus (HPIV), the State Key Laboratory of Virology (Wuhan University, Wuhan Institute of Virology, Chinese Academy of Sciences) Chen Mingzhou After extensive virological and cell biology experiments, it was found that human parainfluenza virus induced mitochondrial autophagy, and the viral matrix protein as a receptor induced the occurrence of mitochondrial autophagy in the host cell independent of the Parkin-PINK1 pathway.
It is reported that the viral matrix protein acts as a "bridge" to pull the mitochondria onto the autophagosome and is surrounded by autophagosomes, blocking the signaling pathway of type I interferon and inhibiting the production of interferon, thus allowing the virus to escape the body. The immune response. The viral polymerase protein prevents the fusion of autophagosomes and lysosomes, leading to the accumulation of autophagosomes and increased virion propagation.
This finding clarifies that different proteins of the virus can cooperate to regulate the autophagy process of the cells, thereby maximally evading the host cell immune response and utilizing the bilayer membrane structure of the autophagosome to facilitate its own replication. This work provides clues to elucidate the molecular mechanisms of viral infection and pathogenesis, and lays the foundation for the design of novel antiviral therapeutic targets. The research results were published in 2017 in the international academic journal Cell Host & Microbe.
It is understood that human parainfluenza virus is one of the main pathogens causing respiratory infections in infants and children with immunodeficiency. The virus is infected by contact with the human eye, the mucous membranes of the mouth or nose, or by inhaling droplets of respiratory secretions caused by sneezing and coughing, which eventually leads to acute bronchiolitis, pneumonia and asthma, which causes each year. Tens of thousands of patients are hospitalized, and there are currently no vaccines and antiviral drugs that can effectively prevent and treat human parainfluenza infection.
Source: People's Network
Pain Relief Patch for Breast
[Name] Medical Cold Patch
[Package Dimension] 10 round pieces
The pain relief patch is composed of three layers, namely, backing lining, middle gel and protective film. It is free from pharmacological, immunological or metabolic ingredients.
[Scope of Application] For cold physiotherapy, closed soft tissue only.
[Indications]
The patches give fast acting pain relief for breast hyperplasia, breast fibroids, mastitis, breast agglomera tion, swollen pain.
[How To Use a Patch]
Please follow the Schematic Diagram. One piece, one time.
The curing effect of each piece can last for 6-8 hours.
[Attention]
Do not apply the patch on the problematic skin, such as wounds, eczema, dermatitis,or in the eyes. People allergic to herbs and the pregnant are advised not to use the medication. If swelling or irritation occurs, please stop using and if any of these effects persist or worsen.notify your doctor or pharmacist promptly. Children using the patch must be supervised by adults.
[Storage Conditions]
Store below 30c in a dry place away from heat and direct sunlight.
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