With a tube of blood to detect cancer, this is the common dream of the global medical community for decades. Liquid biopsy techniques attempt to capture relevant tumor information from the blood using a variety of techniques, thereby circumventing the limitations of traditional methods requiring surgery and puncture sampling. This article will present progress in the field of in vitro biopsy in 2016 from multiple dimensions such as technology, research, market, capital, and policy.
"Liquid biopsy" new technology
At present, the tests involved in body fluid biopsy mainly include the detection of free circulating tumor cells (CTCs), tumor DNA (ctDNA), circulating RNA (Circulating RNA) and exosomes (having a variety of proteins related to cell origin, Lipids, DNA, RNA, etc.). Among them, ctDNA, RNA and exosomes are substances secreted by the tumor itself or released when the tumor cells die.
CTC detection is easy to enrich, ctDNA enrichment is difficult to detect, ctDNA has a strong tumor representative, and exosomes have strong stability. (For details, see Flint's liquid biopsy report in the middle of 2016. "Liquid biopsy" global investment and financing list hits!|hsmap series)
Table 1. Comparison of liquid biopsy techniques
2016 research new findings / new developments
In recent years, the research heat of liquid biopsy has been rising, and the results have become more and more significant, especially in the field of tumor resistance. What changes will the liquid biopsy bring to cancer treatment? Let's take a look at some of the results of the 2016 study. (News from the HSMAP information section)
Table 2. Clinical study quantity time distribution
table 3. Annual patent application (orange line), public quantity trend
According to the data analysis report created by Flint, the number of patents for liquid biopsy has increased rapidly. The number of clinical studies is also on the rise. At present, 16 domestic clinical trials have reached 66 cases, indicating that liquid biopsy technology is receiving more and more attention in basic scientific research.
Table 4. Liquid biopsy indication distribution pie chart
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