Eli L GLP-1 agonist combined with SGLT-2 inhibitor can significantly improve blood glucose levels
February 28, 2018 Source: Sina Pharmaceutical
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];On February 26, data from a new clinical 3b study, AWARD-10, showed that when Trulicity (dulaglutide) was combined with sodium-glucose co-transporter-2 (SGLT-2) inhibitors for type 2 diabetes, significant Improve A1C (average blood glucose concentration of 2-3 months). Relevant research data has been published online in The Lancet Diabetes & Endocrinology. Dulaglutide is a weekly glucagon-like peptide-1 (GLP-1) receptor agonist developed by Eli Lilly and Company to improve blood sugar in adult patients with type 2 diabetes. Trulicity should be combined with diet and exercise.
Dr. Bernhard Ludvik, associate professor of medicine at Rudolfstiftung Hospital in Vienna, and a principal researcher at AWARD-10, said: "In my medical practice, I found that even in the case of effective oral drugs such as SGLT-2 inhibitors and metformin, many adults with type 2 diabetes Additional treatment may still be needed to control their blood glucose levels. The results of this AWARD-10 show that once a week, the combination of Trulicity and SGLT-2 inhibitors is very helpful in helping more patients with type 2 diabetes achieve their treatment goals. Big prospects."
At the 24-week study end point, compared with placebo and SGLT-2 inhibitors (-0.54%), the 1.5 mg and 0.75 mg Trulicity supplemented with SGLT-2 inhibitors showed significant The high blood sugar control effect (Trulicity 1.5 mg and 0.75 mg respectively reached -1.34%, -1.21%). In addition, more patients in the Trolicity group achieved A1C levels below 7% and below 6.5%:
· Trulicity 1.5 mg: 71% (<7%); 50% (≤6.5%);
· Trulicity 0.75 mg: 60% (<7%); 38% (≤ 6.5%);
· Placebo: 32% (<7%); 14% (≤6.5%)
The study also showed that the average weight loss (-3.1 kg) of 1.5 mg of Turicity combined with SGLT-2 inhibitor was greater compared with placebo (-2.1 kg). The average weight loss in the 0.75 mg group was -2.6 kg.
The most common adverse events associated with Trulicity treatment were associated with the gastrointestinal tract and were consistent with previous results. The incidence of Trulicity 1.5mg, 0.75mg, and placebo was nausea (15%, 5%, 4%), vomiting (4%, 3%, 1%) and diarrhea (6%, 10%, 3%). . One case of severe hypoglycemia was recorded in the 0.75 mg group. No new security issues related to Trolicity were found.
Dr. Brad Woodward, senior director of Eli Lilly Diabetes, said: "There are some patients with type 2 diabetes who may need to increase their injection therapy to cope with the progression of the disease, based on diet, exercise and oral medication. AWARD-10 study shows When used in combination with SGLT-2 inhibitors and metformin, the drug provides effective and safe therapeutic effects in patients with type 2 diabetes." (Sina Medical Compilation/David)
Article Reference Source: New Data Show Lilly's Trulicity® (dulaglutide) in Combination with an SGLT-2 Inhibitor Improves Blood Sugar Control in People with Type 2 Diabetes
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